报告题目：Revealing neural dynamical structure of C. elegans with deep learning

报告时间：2024-05-10  15:00-17:00

报 告 人：李春贺 副教授 (复旦大学）

报告地点：武汉大学老外楼317

Abstract：C. elegans serves as a common model for investigating neural dynamics and functions of biological neural networks. Data-driven approaches have been employed in reconstructing neural dynamics. However, challenges remain regarding the curse of high-dimensionality and stochasticity in realistic systems. In this study, we develop a deep neural network (DNN) approach to reconstruct the neural dynamics of C. elegans and study neural mechanisms for locomotion. Our model identifies two limit cycles in the neural activity space: one underpins basic pirouette behavior, essential for navigation, and the other introduces extra Ω turns. The combination of two limit cycles elucidates predominant locomotion patterns in neural imaging data. The corresponding energy landscape explains the switching strategies between two limit cycles, quantitatively, and provides testable predictions on neural functions and circuit roles. Our work provides a general approach to study neural dynamics by combining imaging data and stochastic modelling.